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副教授

孙承操

作者:   发布时间:2018-12-24  浏览次数:

姓名:孙承操

职务、职称:副教授、硕士生导师

系别:预防医学系

邮箱:chengcaosun@whu.edu.cn, CSun8@mdanderson.org

电话:18162634120


个人简介和研究兴趣:


孙承操,博士,硕士生导师,博新计划入选者,伟德betvictor-伟德betvictor官网-伟德betvictor中文官网客服副教授。2008年至2013年在南昌大学公共卫生学院,获预防医学学士学位。2013年至2017年在伟德betvictor-伟德betvictor官网-伟德betvictor中文官网客服硕博连读,获劳动卫生与环境卫生学博士学位。攻读博士学位期间获得多次国家奖学金,武汉大学研究生学术创新奖,武汉大学医学部年度突出贡献奖,雷军奖学金,武汉大学研究生十大学术之星等荣誉称号和奖项。2017年获得第二届全国博士后创新人才支持计划,当年全国仅入选300人。迄今在Cancer Letters, The Journal of Biological Chemistry, Journal of Gastroenterology, Molecuar Therapy-Nucleic Acids, Aging-US, Cell proliferation, Cancer Gene Therapy, Journal of Applied Physiology, Molecular Biosystems, Curr Pharm Des, Clin Chim Acta, Gene, BBRC等与本专业相关的专业杂志上发表第一作者/通讯作者论文25篇。个人发表SCI论文总计影响因子>130,他引>1300次,H因子=191篇研究型论文被列为ESI热点论文(1次)。7篇研究型论文被列为ESI高被引论文(42次)。发表的原创性研究论文被Cell, Circulation, Lancet Global Health, ACS Nano, Journal of Clinical Investigation, Nature Reviews Nephrology, Genome Biology, Pharmacology & Therapeutics, Clin Cancer Res, Cancer Res等高水平杂志正面引用。作为多个学术期刊的特约审稿人,包括: Oncogene, Molecular Therapy, Cancer Letters, Molecular Cancer, The Journal of Clinical Endocrinology & Metabolism, International Journal of Cancer, Mol Ther Nucleic Acids等。 担任Journal of Translational Medicine, Current Pharmaceutical Design, Journal of Thoracic Disease, Current Medicinal Chemistry, Frontiers in Physiology, Biotarget杂志的编委/责任编辑或客座编辑。主持国家自然科学基金1项,博士后创新人才支持计划1项,中国博士后科学基金面上项目1等资助1项,职业危害识别与控制湖北省重点实验室开放基金1项,湖北省卫生健康委员会医学科研项目1项,武汉大学自主科研项目2项,伟德betvictor-伟德betvictor官网-伟德betvictor中文官网客服自主科研项目1项。为美国生物化学与分子生物学协会会员,美国癌症研究协会会员,美国基因和细胞治疗协会员,中东分子生物协会会员。


主要研究领域:非编码RNA在肿瘤发生发展过程中的功能分析及机制探索;抗氧化剂在肌萎缩症中作用机制研究。


主持科研项目:

1. 国家自然科学基金青年项目,转录因子YY1介导的LINC00665通过调控APC/β-catenin信号途径参与非小细胞肺癌的发生与转移,项目编号:81802285,在研,2019.01-2021.12,主持,21万元;

2. 中国博士后创新人才支持计划,长链非编码RNA DANCR在非小细胞肺癌发生与转移中作用机制的研究,项目编号:BX201700178在研,2017.05-2019.08,主持,60万元;

3. 中央高校专项基础研究基金,LINC00301/HIF1α途径在肺癌发生与转移的功能分析及机制探索,项目编号:2042018kf0025,在研,2018.01-2019.12,主持,15万元;

4. 伟德betvictor-伟德betvictor官网-伟德betvictor中文官网客服自主科研项目,YY1/LINC00665/APC/β-catenin信号途径在非小细胞肺癌发生与转移的功能分析及机制探索,在研,2018.09-2020.08,主持,10万元;

5. 中国博士后科学基金面上项目/1等资助,长链非编码RNA LINC00301在肺癌中的作用及其分子机制,项目编号:2017M00340,在研,2017.11-2019.10,主持,8万元;

6. 湖北省卫生健康委员会2019-2020 年度青年人才项目,YY1介导的LINC00665/APC/β-catenin信号途径在非小细胞肺癌发生与转移的作用及机制,项目编号:WJ2019Q039,在研,2019.01-2020.12,主持,4万元;

7. 职业危害识别与控制湖北省重点实验室开放基金青年项目,LINC00301/EZH2/EAF2/HIF1α信号轴在非小细胞肺癌中作用机制的研究,项目编号:OHIC2017Y022017.10-2019.10,在研,主持,1万元;

8. 中央高校专项基础研究基金,莱菔硫烷通过激活Nrf2信号途径抑制TGF-belta/Smad 信号通路抑制肌萎缩小鼠肌肉纤维化,项目编号:2015305020202,已结题,2015.05-2017.12,主持,2.3万元。


参与科研项目:

1. 国家自然科学基金面上项目,Sirt1 在杜氏肌营养不良症中作用机制的研究,NO. 81271943,在研,2013/01-2016/12,参与,70万元;

2. 中央高校基本科研业务费专项基金项目,不同类型和来源活性氧自由基在 DMD 病理发生中的作用,已结题,2013/01-2014/12,参与,40万元;

3. 武汉市卫计委医学科研项目,WG18Q01miR-542-3p靶向抑制USP25信号途径调控肺癌细胞增殖和凋亡的机制研究,在研,2018/05-2020/05,参与,8万元;

4. 武汉市科技局高新技术产业科技创新团队计划项目,新肺癌标志物,miRNAs,在肺癌诊断治疗中的作用,编号:2015070504020219,已结题,2015/01-2017/12,参与,20万元。


5年代表性通讯作者论著:

第一作者论文

1. Sun CC, Zhou Q, Hu W, Li SJ, Zhang F, Chen ZL, Li G, Bi ZY, Bi YY, Gong FY, Bo T, Yuan ZP, Hu WD, Zhan BT, Zhang Q, Tang QZ, Li DJ. Transcriptional E2F1/2/5/8 as potential targets and transcriptional E2F3/6/7 as new biomarkers for the prognosis of human lung carcinoma. Aging (Albany NY). 2018. 10(5):973-987. (IF 5.179) (第一作者)

2. Sun, CC, Zhang, L, Li G, Li, SJ, Chen, ZL, Fu, YF, Gong, Bai, Tao, Zhang, DY, Wu, QM, Li, DJ. The lncRNA PDIA3P interacts with miR-185-5p to modulate oral squamous cell carcinoma progression by targeting cyclin D2. Mol Ther Nucleic Acids, 2017. 9:100-110 (IF 5.660).(第一作者)(通讯作者)

3. Sun, CC, Li, SJ, Li G, Hua, R, Zhou, XH, Li, DJ. Long intergenic non-coding RNA 00511 acts as an oncogene in non-small cell lung cancer by binding to EZH2 and suppressing p57. Mol Ther Nucleic Acids, 2016. 5(11): e385. (IF 5.660)(第一作者)

4. Sun, CC, Li, SJ, Zhang, F, Zhang, Y, Zuo, Z, Xi, YY, Wang, L, and Li, DJ. The novel miR-9600 suppresses tumor progression and promotes paclitaxel sensitivity in non-small cell lung cancer (NSCLC) through altering STAT3 expression. Mol Ther Nucleic Acids, 2016. 5(11): e387. (IF 5.660) (第一作者)

5. Sun, C, Li, S, Zhang, F, Xi, Y, Wang, L, Fu, Z, Zhang, Y, Bi, Y, and Li, D. Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway. Oncotarget.2016, 7(32), 51784-51814. (IF 5.168) (第一作者)

6. Sun CC, Li SJ, Yang CL, Xue RL, Xi YY, Wang L, Zhao QL and Li DJ. Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-kappaB Signaling Pathway. J Biol Chem. 2015; 290(29):17784-17795. (IF 4.010)

7. Sun, C, Li, S, Yuan, Z, Li, D. MicroRNA-346 facilitates cell growth and metastasis, and suppresses cell apoptosis in human non-small cell lung cancer by regulation of XPC/ERK/Snail/E-cadherin pathway. Aging.2016, 8(10), 1509-24. (IF 5.179) (第一作者)

8. Sun, C, Li, S, Li, D. Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1. Oncotarget.2016, 7(24), 35960-35978. (IF 5.168) (第一作者)

9. Sun, CC, Li, SJ, Zhang, F, Pan, JY, Wang, L, Yang, CL Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer. Oncotarget, 7(16):21510-21526. (IF 5.168) (第一作者)

10. Sun, C, Huang, C, Li, S, Yang, C, Xi, Y, Wang, L Hsa-miR-326 targets CCND1 and inhibits non-small cell lung cancer development. Oncotarget.2016, 7(7):8341-8359. (IF 5.168) (第一作者)

11. Sun C, Sang M, Li S, Sun X, Yang C, Xi Y, Wang L, Zhang F, Bi Y, Fu Y and Li D. Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met. Oncotarget. 2015, 6(37):39756-39792. (IF 5.168) (第一作者)

12. Sun C, Li S and Li D. Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-beta/Smad signaling. J Appl Physiol (1985). 2016; 120:377-390. (IF 3.256) (第一作者)

13. Sun, C., Li, S., Yang, C., Xue, R., Xi, Y., Wang, L., Wang, S., He, Q., Huang, J., Xie, S., Jiang, W., & Li, D. (2015). Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation. Oncotarget, 6(28), 25533-25574. (IF 5.168) (第一作者)

14. Sun, C., Yang, C., Xue, R., Li, S., Zhang, T., Pan, L., Ma, X., Wang, L. and Li, D. (2015) Sulforaphane alleviates muscular dystrophy in mdx mice by activation of Nrf2. J Appl Physiol (1985), 118, 224-37. (IF 3.256) (第一作者)

15. Sun, C, Li, S, Yang, C, Xi, Y, Wang, L, Zhang, F MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6. Biochem Biophys Res Commun:2016;471:82-88. (IF 2.559) (第一作者)

16. Yang C*, Sun C*, Liang X, Xie S, Huang J, and Li D. Integrative analysis of microRNA and mRNA expression profiles in non-small-cell lung cancer. Cancer Gene Therapy.2016, 23(4):90-97. (IF 4.044)(co-first author) (共同第一作者)

17. Pan J#, Sun C#, Li S, Huang J, Li D. Role of miR-10b in non-small cell lung cancer (NSCLC) cells by targeting Klotho. Can Cell Microenviron 2015; 2: e936. doi: 10.14800/ccm.936. (co-first author) (共同第一作者)

18. Sun C, Pan J, Li S and Li D. (2015) The Role of Sulforaphane on Duchenne Muscular Dystrophy by Activation of Nrf2.Interdiscip J Microinflammation 2: e104.  doi:10.4172/ijm.1000e104(第一作者)

19. Sun C, Li S and Li D. The role of miR-139-5p and miR-206 in non-small cell lung cancer (NSCLC) by targeting c-Met. Can Cell Microenviron 2016; 3: e1157. doi: 10.14800/ccm.1157. (第一作者)


通讯作者

1. Hu W, Bi ZY, Chen ZL, Liu C, Li LL, Zhang F, Zhou Q, Zhu W, Song YY, Zhan BT, Zhang Q, Bi YY, Sun CC#, Li DJ#. Emerging landscape of circular RNAs in lung cancer. Cancer Lett. 2018 Jul 28;427:18-27. (IF 6.491)(通讯作者)

2. Zhou Q, Hu W, Zhu W, Zhang F, Lin-Lin L, Liu C, Songyang YY, Sun CC#, Li D. Long non coding RNA XIST as a prognostic cancer marker - A meta-analysis. Clin Chim Acta. 2018 Jul;482:1-7. (IF 2.926)(通讯作者)

3. Li DJ, Sun CC#. Editorial: Towards MiRNA Based Therapeutics for Lung Cancer. Curr Pharm Des. 2018 Feb 12;23(39):5971-5972. (IF 2.757) (通讯作者)

4. Zhang ZW, Chen JJ, Xia SH, Zhao H, Yang JB, Zhang H, He B, Jiao J, Zhan BT, Sun CC#. Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2. Gene. 2018 Apr 15;650:60-67. (IF 2.498) (通讯作者)

5. Pan JY*, Zhang F*, Sun CC*#, Li SJ, Li G, Gong FY, He J, Hua RX, Hu WD, Yuan ZP and Li DJ#. MiR-134: a human cancer suppressor? Mol Ther Nucleic Acids, 2017. 6(1):140-149 (IF 5.660) (共同第一作者)(共同通讯作者)

6. Pan JY*, Sun CC*#, Huang SX, Bi ZY, Chen ZL, Li SJ, Li QQ, Wang YX, Bi YY, Wang X, and Li DJ#. MiR-206/133b cluster: a weapon to against lung cancer? Mol Ther Nucleic Acids, 2017. 8:442-449 (IF 5.660) 共同第一作者)(共同通讯作者)

7. Fang, J, Sun, CC#, Gong, C#. Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression. Biochem Biophys Res Commun:2016;478:811-17. (IF 2.559) (通讯作者)

8. Zhou Q, Huang SX, Zhang F, Li SJ, Liu C, Xi YY, Wang L, Wang X, He QQ, Sun CC#, Li DJ#. MicroRNAsa novel potential biomarker for diagnosis and therapy with Non-small cell lung cancer. Cell Prolif. 2017 Dec;50(6). doi: 10.1111/cpr.12394. (IF 4.936) (通讯作者)

9. Li G, Fang J, Wang Y, Wang H# and Sun CC#. MiRNA-based therapeutic strategy in lung cancer. Curr Pharm Des. 2018 Feb 12;23(39):6011-6018. (IF 2.757) (通讯作者)



其他作者

1. Huang, C.F., Sun, C.C., Zhao, F., Zhang, Y.D. and Li, D.J. (2015) miR-33a levels in hepatic and serum after chronic HBV-induced fibrosis. J Gastroenterol, 50,480-90. (IF 5.561)

2. Huang J, Sun C, Wang S, He Q and Li D. microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells. Mol Biosyst. 2015; 11(7):2051-2059. (IF 2.759)

3. Wang L, Zhang T, Sun C, Xue R, Yang C, Xi Y, Li D. Sirt1 Promotes C2C12 Myoblast Cell Proliferation Involving Myostatin Signaling Pathway. Mol Med Rep. 2016, 14(2):1309-15. (IF 1.922)

4. Wang L, Xue R, Sun C, Yang C, Xi Y, Zhang F, He Q, Wang S, Zhao F, Zhang Y, Li D. SIRT1 regulates C2C12 myoblast cell proliferation by activating Wnt signaling pathway. Int J Clin Exp Med. 2016. (IF 0.833)

5. Yang C, Pan L, Sun C, Xi Y, Wang L and Li D. Red Meat Consumption and the Risk of Stroke: A Dose-Response Meta-analysis of Prospective Cohort Studies. J Stroke Cerebrovasc Dis. 2016, 25(5):1177-86. (IF 1.598)

6. Xi, YY, Wang, L, Sun, CC, Yang, CL, Zhang, F, and Li, DJ. The novel miR-9501 inhibits cell proliferation, migration and activates apoptosis in non-small cell lung cancer. Med Oncol, 2016. 33(11):124. (IF 2.920)

7. Wang, L, Xi, YY, Sun, CC, Zhang, F, Jiang, H, He, QQ, and Li, DJ. CDK3 is a major target of miR-150 in cell proliferation and anti-cancer effect. Exp Mol Pathol. 2017. (IF 2.566)

8. Huang CF, Wang WN, Sun CC, Wang YQ, Li L, Li Y, et al. Echinocystic acid ameliorates hyperhomocysteinemia-induced vascular endothelial cell injury through regulating NF-kappaB and CYP1A1. EXP THER MED 2017 2017-11-01;14(5):4174-4180. (IF 1.141)

9. Liu C, Hu W, Li LL, Wang YX, Zhou Q, Zhang F, Song-Yang YY, Zhu W, Sun CC, Li DJ. Roles of miR-200 family members in lung cancer: more than tumor suppressors. Future Oncol. 2018 Sep 13. doi: 10.2217/fon-2018-0155. (IF 2.369)